How Semaglutide Aids Weight Loss

Semaglutide aids weight loss as it is a GLP-1 receptor agonist. GLP-1 receptor agonists enhance the incretin effect by activating the GLP-1 receptor. Unlike DPP-4 inhibitors that restore physiological GLP-1 levels, GLP-1 receptor agonists like Semaglutide achieve pharmacological levels, making them more potent.

In addition to their effects on the pancreas to increase insulin secretion and decrease glucagon, GLP-1 receptor agonists also act on the hypothalamus to reduce appetite and food intake, leading to weight loss. The size of this effect has led to the licensing of liraglutide (another GLP-1 receptor agonist) as an anti-obesity treatment.

Clinical trials have demonstrated that human GLP-1 analogues (which includes Semaglutide) reduce weight. As GLP-1 receptor agonists cause weight loss, they are particularly suitable for people with obesity. If there is a pressing need to minimize weight gain or promote loss in individuals with diabetes, GLP-1 receptor agonists or SGLT2 inhibitors are recommended.

Understanding the Brand Difference between Wegovy & Ozempic.

Any particular medicine can come in various names or brands as they are produced by different manufacturers.

In the case of Semaglutide, the following brand names refer to the same product – Semaglutide.

1. Wegovy
2. Ozempic

A closely related medicine is Tirzapatide, a common brand of which is Mounjaro.

Nigerians will be happy to know that Semaglutide (Wegovy & Ozempic) and Tirzapatide (Mounjaro) are available in Nigeria.